Kris Jenner Spills All on Her Ozempic Journey—Jaw-Dropping Results, Side Effects & What’s Next

Kris Jenner is setting the record straight on her brief and unpleasant brush with Ozempic, the Type-2-diabetes drug that has become Hollywood’s hottest off-label weight-loss aid. Speaking on the May 5 episode of the “She MD” podcast, the 70-year-old Kardashian matriarch revealed she “tried it once when no one knew what it was” but quit almost immediately after severe nausea left her unable to work. According to Jenner, the side effects were so debilitating she phoned her longtime OB-GYN, podcast co-host Dr. Thais Aliabadi, to say, “I can’t work anymore. I’m so sick.” The solution was to abandon the GLP-1 injectable in favor of customized peptide shots and a targeted supplement stack—an approach Jenner now calls a “game-changer” for boosting energy, hair, skin and nail health. Beyond peptides, the self-described “momager” keeps her hormones in check with quarterly bloodwork, crediting balanced thyroid and estrogen levels for helping her juggle business deals, 12 grandchildren and 5 a.m. workouts. “After 45, hormone health is everything,” she said, urging both daughters and son Rob to test regularly. Jenner’s confession arrives amid a celebrity Ozempic rethink. Stars from Amy Schumer to Tracy Morgan have publicly detailed intense nausea or rapid weight regain after stopping the drug, while others—Scott Disick, Jonathan Van Ness—praise its slimming power yet warn of lifestyle trade-offs. The FDA has not approved Ozempic for chronic weight management, but surging demand has already caused intermittent shortages nationwide. Health experts note that Ozempic slows stomach emptying and can trigger dehydration, vomiting and gall-bladder issues. Patients are also advised to pair the weekly shot with protein-rich meals and resistance training to preserve muscle mass. Jenner’s experience underscores that the medication is far from a one-size-fits-all fix. Industry watchers say her pivot to peptides could spark a new A-list trend: tailor-made amino-acid blends that aim to improve mitochondrial function without the appetite-crushing misery. Clinics are already marketing “KJ energy drips” and “celebrity peptide protocols,” betting that fans will follow Jenner’s lead just as eagerly as they once Googled “Kardashian Ozempic.” For now, the reality-TV powerhouse is sticking to clean eating, daily Pilates and her doctor-approved injections—proof, she insists, that wellness wins over quick fixes. “It’s about what your body needs,” Jenner told listeners. “Find the path that lets you do life better.”